Due to the Corona numbers, only 50% of the seats may be occupied at football games in Italy, and these around 38,000 seats will also be occupied today.
The last time the two teams met in the league was in September, when Milan beat Lazio 2-0 with relative ease.
His opposite number Maurizio Sarri makes five changes compared to the 3-0 win in Serie A against Fiorentina. Cup goalkeeper Reina comes in for Strakosha, while Hysaj, Bašić, Cataldi and Felipe Anderson start for Lucas Leiva, Lazzari, Luis Alberto and Pedro (all on the bench).
Compared to the 2-1 derby win against Inter at the weekend, coach Stefano Pioli makes two changes. For Saelemaekers and Bennacer (both bench), Brahim Díaz and Junior Messias start today.
In the last round of play, both teams had to go overtime to advance to the quarter-finals. Lazio struggled to a 1-0 win over Udinese, who AC defeated Genoa 3-1 after 120 minutes.
After Inter Milan beat AS Roma 2-0 yesterday and reached the semi-finals, AC and Lazio are now finding the next semi-finalists in the second duel between teams from Milan and Rome.
Good evening and welcome to the Coppa Italia quarter final match between AC Milan and Lazio. Kick-off at San Siro is at 21:00.